CSF-ADA As Diagnostic Tool For Tuberculous Meningitis Patients
Dr Margeyi Mehta*, Dr Jigish Shah**, Dr A T Leuva***.
Abstract Introduction : TB is widely prevalent in India and a common form of TB is Tuberculous Meningitis (TBM), with great mortality, mainly in childhood. Available methods of TBM diagnosis are time-consuming and expensive. ADA is being recognized as marker of T-cell-mediated immunity. There is a need for cost-effective and relatively rapid method at tertiary-healthcare-settings. The study was carried out to assess the role of CSF-ADA for TBM diagnosis. Materials and Methods : In this cross-sectional study at SSG Hospital, Baroda between June-October 2011, 50 patients and 20 controls were selected. ADA in CSF and other biochemical markers were assessed after due informed consent. Microxpress ADA-MTB reagent was used for CSF-ADA estimation.
Results : Out of 50, 22 children were male and 28 were female. 17 TBM (34%), 19 PM (38%) and 14 AM (28%) cases were detected. 72% of cases had CSF-ADA levels less than 10 IIU/L (mean 4.37±1.32), CSF-ADA levels were less than 10 in all controls (mean 2.8±0.8). Comparative CSF-ADA estimation in TBM, PM and AM showed higher values for TBM (p
The List of Journals Indexed for MEDLINE publication ceased with the 2008 edition. The NLM Catalog can be used to obtain a list of currently indexed MEDLINE titles; select the Limit for Current Subsets called "Currently indexed in MEDLINE."
The List of Serials Indexed for Online Users online publication is designed to provide bibliographic information for serials from which articles are indexed with the MeSH® vocabulary and cited in MEDLINE®, the backbone of the NLM PubMed® database. More detailed bibliographic data and information about indexing coverage for serials cited in MEDLINE/PubMed can be found in LocatorPlus®, the NLM online catalog, and the NLM Catalog, an Entrez database.
Previous print versions of theList of Journals Indexed for MEDLINEmight be available from the U.S. Government Printing Office (GPO). Information about ordering documents from GPO is available athttp://www.nlm.nih.gov/pubs/pubcat.html#ordering.
The articles in National Journal of Integrated Research in Medicine are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.