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Serum - Ascites Albumin and Cholesterol Gradients in Differential Diagnosis of Ascites

Sapna Vyakaranam*, Srinivas Nori**, Gurumurthy Sastry M*, Sudhir Bhargav Vyakaranam†,Aparna Varma Bhongir*.

Abstract
Background: Differential diagnosis of ascites is a common clinical problem. Less expensive biochemical techniques are required to differentiate ascites with unknown etiology. Aim: To evaluate the diagnostic efficiency of ascitic fluid cholesterol, serum ascites albumin gradient (SAAG) and serum ascites cholesterol gradients (SACG) in differentiating cirrhotic, tuberculous and malignant ascites. Methods: 50 patients (25 with hepatic cirrhosis, 15 with tuberculosis and10 with malignancy) were evaluated for ascitic fluid total protein, albumin, cholesterol, SAAG and SACG. Results: The mean ascitic fluid cholesterol was significantly higher in malignant ascites when compared with cirrhosis and tuberculous ascites (p= 0.0001 each). The difference between tuberculous and cirrhotic ascites was also significant (p= 0.001). The mean value of SAAG was significantly higher in cirrhosis when compared with tuberculous and malignant ascites (p= 0.0001; p= 0.001 respectively) but the difference between tuberculous and malignant ascites was not significant The mean SACG was significantly lower in malignant compared to tuberculous and cirrhotic ascites (p= 0.0001; p= 0.001 respectively). The difference between tuberculous and cirrhotic ascites was not significant. Conclusion: SAAG is a better marker to differentiate cirrhotic ascites from tuberculous and malignant ascites. Ascitic fluid cholesterol and SACG are better markers to differentiate malignant ascites from cirrhotic and tuberculous ascites. [Vyakaranam S et al. NJIRM 2011; 2(3) : 22-28]

Key words: Cirrhosis, Ascitic fluid cholesterol, Tuberculous peritonitis, Malignant ascites.


 
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How to Cite this Article
Pubmed Style

, Bhongir ,V. Serum - Ascites Albumin and Cholesterol Gradients in Differential Diagnosis of Ascites. NJIRM. 2011; 2(3): 22-28.


Web Style

, Bhongir ,V. Serum - Ascites Albumin and Cholesterol Gradients in Differential Diagnosis of Ascites. http://www.nicpdjournals.com/?mno=10072 [Access: December 12, 2017].


AMA (American Medical Association) Style

, Bhongir ,V. Serum - Ascites Albumin and Cholesterol Gradients in Differential Diagnosis of Ascites. NJIRM. 2011; 2(3): 22-28.



Vancouver/ICMJE Style

, Bhongir ,V. Serum - Ascites Albumin and Cholesterol Gradients in Differential Diagnosis of Ascites. NJIRM. (2011), [cited December 12, 2017]; 2(3): 22-28.



Harvard Style

& Bhongir, ,. V. (2011) Serum - Ascites Albumin and Cholesterol Gradients in Differential Diagnosis of Ascites. NJIRM, 2 (3), 22-28.



Turabian Style

, and ,Aparna Varma Bhongir. 2011. Serum - Ascites Albumin and Cholesterol Gradients in Differential Diagnosis of Ascites. National Journal of Integrated Research in Medicine, 2 (3), 22-28.



Chicago Style

, and ,Aparna Varma Bhongir. "Serum - Ascites Albumin and Cholesterol Gradients in Differential Diagnosis of Ascites." National Journal of Integrated Research in Medicine 2 (2011), 22-28.



MLA (The Modern Language Association) Style

, and ,Aparna Varma Bhongir. "Serum - Ascites Albumin and Cholesterol Gradients in Differential Diagnosis of Ascites." National Journal of Integrated Research in Medicine 2.3 (2011), 22-28. Print.



APA (American Psychological Association) Style

& Bhongir, ,. V. (2011) Serum - Ascites Albumin and Cholesterol Gradients in Differential Diagnosis of Ascites. National Journal of Integrated Research in Medicine, 2 (3), 22-28.



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